ONCOLYTIC VIRUS-MEDIATED REVERSAL OF IMPAIRED TUMOR ANTIGEN PRESENTATION

ONCOLYTIC VIRUS-MEDIATED REVERSAL OF IMPAIRED TUMOR ANTIGEN PRESENTATION

Blog Article

Anti-tumor immunity can eliminate existing cancer cells and also maintain a constant surveillance against possible relapse.Such an antigen-specific adaptive response begins when tumor-specific T cells become activated.T cell activation requires two signals on antigen presenting cells (APCs): antigen presentation through MHC molecules and co-stimulation.

In the absence of one or both of these signals, T cells remain inactivated or can even become tolerized.Cancer cells and their associated microenvironment strategically hinder the processing and presentation of alarecre.com tumor antigens and consequently prevent the development 1073spx of anti-tumor immunity.Many studies, however, demonstrate that interventions that overturn tumor-associated immune evasion mechanisms can establish anti-tumor immune responses of therapeutic potential.

One such intervention is oncolytic virus (OV)-based anti-cancer therapy.Here we discuss how OV-induced immunological events override tumor-associated antigen presentation impairment and promote appropriate T cell:APC interaction.Detailed understanding of this phenomenon is pivotal for devising the strategies that will enhance the efficacy of OV-based anti-cancer therapy by complementing its inherent oncolytic.